摘要
Abstract
Objective To study the feasibility and clinical value of serum protein markers for early diagnosis of liver cancer .Methods A total of 60 patients with hepatocellular carcinoma ( A group ) , 35 patients with liver cirrhosis ( B group ) , 15 patients with other diseases ( C group ) , 15 healthy persons ( control group ) were selected for the study.Venous blood was collected to detect alpha -fetoprotein (AFP), AFP heterogeneity ( AFP-L3 ) , Golgi membrance protein 73 ( CP73 ) , the correlation of tumor size and BCLC classification was analyzed . Results The serum AFP, AFP-L3, GP73 levels in group A were sig-nificantly higher than those in other three groups (P<0.05).There was no significant correlation between tumor size and serum levels of AFP and GP73 , and there was significant correlation between tumor size and serum AFP-L3; no significant correlation between the number of tumors and serum AFP, AFP-L3, CP73.There was a positive correlation between BCLC classification and AFP , AFP -L3 , the sensitivity of AFP was 85.7%, specificity was 72.9%; the sensitivity of AFP -L3 was 58.0%, specificity was 87.6%; the sensitivity of GP73 was 69.7%, specificity was 76.7%.Parallel test joint detection method can improve the sensitivity and negative predictive value of detection; series of tests combined detection method can improve the specificity and positivepredictive value.Conclusion Serum AFP, AFP-L3, CP73 joint detection and using positive complementary can sig-nificantly improve the accuracy of hepatic tumors diagnosis .关键词
血清蛋白/血清甲胎蛋白/甲胎蛋白异质体/高尔基体膜蛋白73/肝癌Key words
serum protein/serum alpha-fetoprotein/alpha-fetoprotein heterogeneity/Golgi membrane protein 73/liver cancer分类
医药卫生
