摘要
Abstract
Objective To observe the effect and safety of metformin com-bined with saxagliptin or glimepiride in patients with type 2 diabetes me-llitus inadequately controlled with metformin alone .Methods Sixty pa-tients with type 2 diabetes mellitus inadequately controled by metformin alone were randomly divided into trial group and control group , 30 pa-tients in each group .The two groups maintain the original dose of met-formin and usage unchanged , patients in trial group were given oral saxa-gliptin 5 mg, once a day , and the patients in control group were treated with glimepiride 1-4 mg once daily before breakfast .The treatment las-ted 12 weeks.The data of fasting plasma glucose ( FPG) , 2 h postpran-dial plasma glucose(2 h PG), hemoglobin A1c(HbA1c), lipids weight, fasting insulin ( FINS) , homeostasis model assessment of β-cell function ( HOMA -β) were recorded and compared between the two groups . Results The serum levels of FPG , 2 h PG and HbA1 c were significantly decreased in two groups after treatment ( P<0.05 ) , but had no signifi-cant differences between the two groups .Compared with control group , the levels of FINS and HOMA-βstatistically increased after treatment in the trial group ( P <0.05 ) .There was no serious adverse reaction in both groups during the treatment , the incidence of mild hypoglycemia was significantly less in trial group ( P<0.05 ) . Conclusion The blood glucose control of saxagliptin is comparable to glimepiride , but saxagliptin showed a better effect on the improvement of β-cell function and decrease of the risk of hypoglycaemia .关键词
2型糖尿病/二甲双胍/沙格列汀/空腹血糖/糖化血红蛋白Key words
type 2 diabetes mellitus/metformin/saxagliptin/fasting plasma glucose/hemoglobin A1c分类
医药卫生
