中国临床药理学杂志Issue(20)：1987-1989,3.DOI:10.13699/j.cnki.1001-6821.2015.20.001
多药联合治疗细菌感染致小儿过敏性紫癜的临床疗效与安全性评价
Clinical efficacy and safety of multiple drug combination in the treatment of children with allergic purpura caused by bacterial infection
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of multiple drug treatment of children with allergic purpura caused by Myco-plasma pneumonia or Helicobacter pylori.Methods Seventy-one chil-dren diagnosed of allergic purpura were divided into group A ( mycoplas-ma pneumonia positive, n=38) and group B ( Helicobacter pylori posi-tive, n=33).All of included 71 cases were administered anti-anaphy-laxis as the basic treatment modality.Patients in the group A were also treated with azithromycin 10 mg・ kg -1 , qd po with 1-3 days a week for 3 weeks. Patients in the group B were given clarithromycin 15 mg・ kg-1・ d -1 , qd +amoxicillin 50 kg・ d -1 , tid +omeprazole 0.8 kg・ d-1 , qd po for 3 weeks.After treatment, the clinical efficacy, toxicity and recurrence rate for the next 6 months were evaluated between the two groups.Results The clinical efficacy were 89.5%and 87.9%in the group A and B, respectively, without statistical difference ( P>0.05) .Nine and seven cases were found recurrence in group A and B, with no significant difference between the two groups ( P >0.05 ) . There were 2 and 1 nausea and vomiting cases in the group A and B respectively without statistical difference ( P >0.05 ) .Conclusion It was effective and safe for multiple drug treatment of children with allergic purpura caused by Mycoplasma pneumonia or Helicobacter pylori.关键词
过敏性紫癜/肺炎支原体/幽门螺旋杆菌/安全性/临床疗效Key words
allergic purpura/Mycoplasma pneumoniae/Helicobacter pylori/safety/clinical efficacy分类
医药卫生引用本文复制引用
林世光,曾晓明,吴雪梅,林珊,张忠龙,郭瑞官..多药联合治疗细菌感染致小儿过敏性紫癜的临床疗效与安全性评价[J].中国临床药理学杂志,2015,(20):1987-1989,3.基金项目
福州市科技计划基金资助项目 （）
