中国临床药理学杂志Issue(20)：2058-2061,4.DOI:10.13699/j.cnki.1001-6821.2015.20.024
万古霉素血药谷浓度与肾毒性相关性的验证：基于双变量模型的 Meta分析
Validation of relationship between vancomycin trough concentration and nephrotoxicity:A Meta-analysis based on bivariate model
门鹏 1李慧博 2翟所迪1
作者信息
- 1. 北京大学第三医院药剂科，北京 100191
- 2. 北京大学 药学院 药事管理与临床药学系，北京 100191
- 折叠
摘要
Abstract
Objective To evaluate the association between vancomycin trough concentrations and incidence of nephrotoxicity . Methods Pubmed, EMbase, Cochrane Library, China National Knowledge Infra-structure ( CNKI ) , WanFang Data and Chinese Bio Medical Literature Database ( CBM) were systematically searched from inception to February 2014.Specificity, sensitivity and predictive odds ratios with 95% confi-dence intervals were calculated.Results Seventeen observational stu-dies and 2802 patients were included in the Meta-analysis.While cut-offs of trough concentrations were 10 , 15 or 20 mg・ L-1 , pooled sensi-tivity were 0.83, 0.69 or 0.43, pooled specificity were 0.35, 0.61 or 0.83 , pooled predictive odds ratios were 2.65 , 3.60 or 3.85. Conclusion There is definitive association between vancomycin trough concentrations ( ascending from 10 to 20 mg・ L-1 ) and incidence of nephrotoxicity.Trough concentration is an appropriate parameter of thera-peutic drug monitoring of vancomycin.关键词
万古霉素/谷浓度/肾毒性/双变量模型/Meta分析Key words
vancomycin/trough concentration/nephrotoxicity/bivariate model/Meta-analysis分类
医药卫生引用本文复制引用
门鹏,李慧博,翟所迪..万古霉素血药谷浓度与肾毒性相关性的验证：基于双变量模型的 Meta分析[J].中国临床药理学杂志,2015,(20):2058-2061,4.
