中国临床药理学杂志Issue(20)：2076-2079,4.DOI:10.13699/j.cnki.1001-6821.2015.20.030
β－片层阻断肽用以治疗阿尔茨海默病的研究进展
Research progress on β-Sheet breaker peptides in treatment of Alzheimer′s disease
摘要
Abstract
Alzheimer′s disease ( AD ) is a common neurodegenerative disorder that causes progressive memory and cognitive impairment and ul-timately leads to death of patients.Aggregation of amyloid β-peptide ( Aβ) is a central event in AD pathogenesis, which is based onβ-sheet formation of Aβpeptides.β-Sheet breaker peptides are oligopeptides that can prevent and/or reverse β-sheet formation and thus represent a promising class of candidates for treatment of AD. This review is to summarize the progress of β-Sheet breaker peptides made in the past few decades.关键词
阿尔茨海默病/老年痴呆症/β-淀粉样肽/β片层阻断肽Key words
Alzheimer ’ s disease/dementia/amyloid β-peptide/β-Sheet breaker peptide分类
医药卫生引用本文复制引用
郭建军,权腾飞,赵永跃,谈伟锋,朱凌宇,朱晶,李梦莎,卜海之..β－片层阻断肽用以治疗阿尔茨海默病的研究进展[J].中国临床药理学杂志,2015,(20):2076-2079,4.基金项目
苏州科学技术局姑苏创新创业领军人才基金资助项目 （）
