中国临床药理学杂志Issue(21)：2105-2107,3.DOI:10.13699/j.cnki.1001-6821.2015.21.006
健康成年人糖代谢调节状态与血清25羟维生素 D3水平关系研究
Study of relationship between the state of sugar metabolic regulation and serum 25-hydroxyl Vitamin D3 levels of healthy adults
摘要
Abstract
Objective To investigate the relationship between the state of sugar metabolic regulation and serum 25 -hydroxyl Vitamin D3[25(OH)D] levels of healthy adult. Methods A total of 102 healthy adults who were received health examination in our hospital were enroll for the study.Their state of sugar metabolic regulation were evalua-ted through the homeostasis model assessment B cell function index ( HOMA-B) , secretion index ( IS ) , the sensitive index ( IAI ) , and insulin resistance index ( HOMA-IR).Healthy adults cases were divid-ed into the 25( OH) D reduction group and normal group according to the serum 25 ( OH ) D level. Clinical data were compared between two groups.25 ( OH ) D, HOMA-B, IS, HOMA -IR followed abnormal distribution were analyzed by logarithmic transformation. Pearson correlation analysis and multiple linear regression analysis were performed to investigate the relationship between the index of sugar metabolic regulation and serum 25-hydroxyl Vitamin D3 levels. Results The serum 25(OH)D level of 64 cases (62.7%) decreased.Lg(HOMA-B), Lg(IS), IAI of the 25(OH)D reduction group were significantly higher than those of normal group ( P<0.05 ) , and Lg ( HOMA -IR ) was significantly lower than that of normal group(P<0.05).Lg[25(OH)D] was positively correlated with Lg(HOMA-B), Lg(IS),IAI(P<0.05),andnegativelycorrelatedwithLg(HOMA-IR)(P<0.05).Conclusion 25(OH)D could improve the function of pancreatic islet B cell and sensitivity of insulin, thus the adults with decreased serum 25 ( OH) D level are advised to receive appropriate VD supplement.关键词
25-羟维生素D3/胰岛B细胞功能/胰岛素抵抗Key words
25-hydroxyl vitamin D3/pancreatic islet B cell function/insulin resistance分类
医药卫生引用本文复制引用
李明霞,史丽,赵轶峰,郝伟芳,左丽娟,张明慧,任卫东,谷君..健康成年人糖代谢调节状态与血清25羟维生素 D3水平关系研究[J].中国临床药理学杂志,2015,(21):2105-2107,3.基金项目
河北省卫计委医学科学研究重点课题计划基金资助项目（20150055）；张家口市科技局指令性计划基金资助项目 （）
