中国临床药理学杂志2015，Vol.31Issue(22)：2184-2186,3.DOI:10.13699/j.cnki.1001-6821.2015.22.002
万古霉素对新生儿败血症患儿的临床预后及免疫功能的影响
Influence of vancomycin on clinical outcomes and immune function of neonatal sepsis
摘要
Abstract
Objective To study the influence of vancomycin on clinical effects and immune function of neonatal sepsis.Methods A total of 53 neonatal sepsis treated in our hospital were selected as the test group, and 53 health normal newborns in the same period in our hospital were selected as the control group.All neonatal sepsis were treated with cefa-thiamidine combined with piperacillin sulbactam, and neonatal sepsis that infected by methicillin-resistant Staphylococcus aureus were treated with vancomycin 15 mg·kg-1 , 1 times a day, and 7 -10 d was a course.After treatment, clinical efficacy and adverse reactions of chil-dren in test group were observed. Soluble interleukin -2 receptor ( sIL-2R) , immunoglobulin G ( IgG ) , immunoglobulin M ( IgM ) , membrance interleukin -2 receptor ( mIL -2 R ) of children changes before and after treatment were compared in two groups.Results After treatment, immune function indicators of neonatal sepsis and normal newborns were compared which showed no significant difference (P>0.05).After vancomycin treatment, total effective rate of neonatal sepsis was 85.72%, which was higher than that before treated with vancomycin (28.57%, P<0.05); and immune function parameters of newborns with Staphylococcus aureus septicemia was improved obviously, which had no significant difference compared with that of normal newborns ( P>0.05).The incidence of adverse reactions such as rash, nausea, vomiting, diarrhea and phlebitis before and after treatmemt with vancomycin had no significant difference ( P >0.05 ) . Conclusion Vancomycin can effectively improve the immune function in children with neonatal sepsis and reduce ad-verse drug reactions, which can be also conducive to clinical outcomes of children.关键词
万古霉素/新生儿败血症/免疫功能/不良反应/疗效Key words
vancomycin/neonatal sepsis/immune function/adverse drug reaction/efficacy分类
医药卫生引用本文复制引用
陈兴月..万古霉素对新生儿败血症患儿的临床预后及免疫功能的影响[J].中国临床药理学杂志,2015,31(22):2184-2186,3.基金项目
海南省卫生厅医学科研课题基金资助项目(琼卫2013-043号) （琼卫2013-043号）
