中国临床药理学杂志2015，Vol.31Issue(22)：2226-2228,3.DOI:10.13699/j.cnki.1001-6821.2015.22.016
氯诺昔康与舒芬太尼用于口腔颌面外科手术后自控镇痛的临床疗效及安全性评价
Clinical efficacy and safety of lornoxicam or sulfentanyl on controlled intravenous analgesia after oral and maxillofacial operation
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of lor-noxicam or sulfentanyl on patient controlled intravenous analgesia ( PCIA ) in postoperative patients with oral and maxillofacial operation ( OMS).Methods Fifty-eight patients with oral and maxillofacial op-eration were randomly divided into treatment group ( n=28 ) and control group ( n=30 ) .Patients in the treatment group were given lornoxicam 32 mg+granisetron 3 mg+0.9% NaCl up to 100 mL PCIA.And pa-tients in the control group were administrated of sulfentanyl 1 mg·kg -1+granisetron 3 mg+0.9% NaCl up to 100 mL PCIA.After operation 4, 8, 12, 24 and 48 h, the pain control satisfaction and PCIA related adverse drug reactions such as nausea and vomiting and dizzy were evalu-ated between the two groups.Results The pain control, sedation effects and pain relief satisfaction had no statistical difference between the two groups in the above time points ( P>0.05 ) .The PCIA related nausea and vomit or dizzy in treatment group was 3.6% which was significant lower than that in control group 23.3%(P<0.05).Conclusion Com-pared with sulfentanyl, Lornoxicam had the same pain control and seda-tion effects for PCIA in patients with oral and maxillofacial operation, but with less nausea and vomiting or dizzy adverse drug reactions.关键词
舒芬太尼/氯诺昔康/术后自控镇痛/口腔颌面部手术/不良反应Key words
sulfentanyl/lornoxicam/patient controlled intravenous analgesia/oral and maxillofacial operation/adverse drug reaction分类
医药卫生引用本文复制引用
朱雪美,闫俊杰..氯诺昔康与舒芬太尼用于口腔颌面外科手术后自控镇痛的临床疗效及安全性评价[J].中国临床药理学杂志,2015,31(22):2226-2228,3.基金项目
浙江中医药科技计划基金资助项目(2009GA002) （2009GA002）
