中国临床药理学杂志2015，Vol.31Issue(22)：2229-2231,3.DOI:10.13699/j.cnki.1001-6821.2015.22.017
丙泊酚或依托咪酯麻醉对幼儿近远期认知功能的影响
Short and long term effect of etomidate or propofol anesthesia on cognitive function of infants
摘要
Abstract
Objective To compare the effects of etomidate and propofol anesthesia on short -term and long -term cognitive ability of infants. Methods A total of 100 infants aged from 1 to 3 years old who were undergoing hernia repair surgery were randomly divided into propofol group ( group A) , etomidate anesthesia group ( group B) , each group 50 infants; another 50 healthy infants at the same age as control group ( group C).Group A and B were respectively given the induction of an-esthesia propofol 1-3 mg·kg-1 and etomidate 0.1-0.4 mg·kg-1 , on the basis of fentanyl (1-2) ×10 -3 mg·kg -1 and rocuronium 0.6-1.2 mg·kg-1 to both groups and giving fentanyl 2 ×10 -3 mg·kg-1 to maintain anesthesia prior to surgery.The infants of group A, B and C attended cognitive ability assessment according to their ages at 1 d before surgery, 3 d and 3 months after surgery by adopting Berry infant perceptions-Ⅲ( BSID -Ⅲ) .The changes of cognitive ability were observed during the three periods.Results Compared with 1 d before surgery, the scores of group A and B were lower than those at 3 d after surgery ( P <0.05 ) , with 10 children ( 20.0%) of post operative cognitive dysfunction( POCD) in group A and 9 (18.0%) in group B.The scores of cognitive ability assessment at 3 months after surgery and incidence of POCD in group A and B had no significant difference (P>0.05).The comparison between group A and B showed that the cognitive scores at 3 d and 3 months after surgery and the inci-dence of POCD had no significant difference ( P >0.05 ) .Conclusion Propofol or etomidate anesthesia can cause reversible cognitive ability decline with varying degrees among infants aged 1-3 years at the early stage after surgery and the cognitive ability can be restored by itself within 3 months after surgery.关键词
丙泊酚/依托咪酯/幼儿/全身麻醉/术后认知功能障碍Key words
propofol/etomidate/infant/general anesthesia/postoperative cognitive dysfunction分类
医药卫生引用本文复制引用
谢景远,蒋奕红,黄志华,熊威威,李爱国,谭毅,梁萌..丙泊酚或依托咪酯麻醉对幼儿近远期认知功能的影响[J].中国临床药理学杂志,2015,31(22):2229-2231,3.基金项目
广西高校学校科研基金资助项目(201204lx243) （201204lx243）
桂林市科学研究与技术开发基金资助项目( 20140310 -2-3) （ 20140310 -2-3）
