中国临床药理学杂志2015，Vol.31Issue(22)：2260-2262,3.DOI:10.13699/j.cnki.1001-6821.2015.22.027
利奈唑胺耐药的粪肠球菌临床分离株的耐药性分析
Resistance spectrum of linezolid resistance enterococcus strains
摘要
Abstract
Objective To explore the condition of various types of anti-biotic resistance of enterococcus isolated in clinical.Methods Agar dilu-tion method and K-B paper diffusion method had been used to test the drug susceptibility of minimum inhibitory concentration ( MIC ) of entero-coccus isolated in clinical and to measure its minimum antibacterial depth.Results A total of 666 strains of enterococcus faecalis were isola-ted from a variety of clinical specimens, and 28 strains were linezolid re-sistance.Among these 28 linezolid resistance strains, the drug resist-ances to quinupristin, tetracyclinet, erythromycin and ciprofloxacin were 100%, 85.7%, 78.6%and 50.0%, respectively.All strains were sen-sitive to amoxicillin, 1 strains were resistant to vancomycin, 17 strains (60.7%) were intermediary resistance to vancomycin, high-level re-sistance to gentamicin was 3.6%.Conclusion Enterococcus faecalis had appeared resistance to linezolid, but the combination of aminoglyco-side and penicillins still has antibacterial activity in vitro to linezolid re-sistant enterococcus faecalis.关键词
粪肠球菌/利奈唑胺/耐药率/抗菌药物Key words
enterococcus faecalis/linezolid/drug resistance/antibiotic分类
医药卫生引用本文复制引用
姚丹,余方友,黄晓颖,徐晓梅,王良兴..利奈唑胺耐药的粪肠球菌临床分离株的耐药性分析[J].中国临床药理学杂志,2015,31(22):2260-2262,3.基金项目
国家 自然 科 学基 金 资助 项 目(81271906) （81271906）
