中国老年保健医学Issue(5)：21-24,4.DOI:10.3969/j.issn.1672-4860.2015.05.006
端粒－端粒酶与衰老退行性变的关系
The relationship between telomere-telomerase and aging development
摘要
Abstract
Aging is a complex control process of multiple factors , involving alterations of DNA damage , DNA methylation , the change of telomere ’ s length and cellular oxidation .In recent years , a lot of theories have been proposed to explain the aging process , and the telomere hypothesis of cellular senescence is becoming one of hot spots .We has known cellular aging is the basis of the or-gan aging or the boby aging , however , cellular senescence is caused by the gradual shortening of telomere length and the change of it’s structure in the process of cell division.The structures and functions of telomere-telomerase or the research progress of the rela-tionship between telomerase and aging are reviewed , which will manifest important theoretic and practical significance in antiaging .关键词
端粒/端粒酶/衰老Key words
telomere/telomerase/aging引用本文复制引用
韩晶,杨泽..端粒－端粒酶与衰老退行性变的关系[J].中国老年保健医学,2015,(5):21-24,4.基金项目
国家自然科学基金项目（81061120527，81370445，81472408）；卫生部公益性研究基金（201302008）；国家科技部十二五支撑计划（2012BAI10B01）；卫计委卫生行业科研专项（201302008）；科技部十二五项目（2012BAI10B01）；国家自然科学基金项目（81370445，81241082）资助 （）
