中国免疫学杂志Issue(11)：1510-1514,1519,6.DOI:10.3969/j.issn.1000-484X.2015.11.015
Caveolin-1、GPR30和 Vimentin 在甲状腺乳头状癌组织中的表达及意义
Expression and significance of Caveolin-1, GPR30 and Vimentin in papillary thyroid carcinoma
摘要
Abstract
Objective:To investigate the expression of Caveolin-1,GPR30 and Vimentin at tumor tissues of human papillary thyroid carcinoma( PTC) patients and analyze their associations for the possible clinical implication.Methods: Immunohistochemistry was used to analyze the expression of Caveolin-1, GPR30 and Vimentin in 76 PTC and 44 normal samples.The correlations of Caveolin-1, GPR30 and Vimentin expression with one another, and with several clinicopathological indicators were statistically analyzed.Results:In PTCs,the positive expression rates of Caveolin-1,GPR30 and Vimentin were 9.21%(7/76),80.26%(61/76) and 76.32%(58/76),respectively.Caveolin-1,GPR30 and Vimentin expression had significant correlations with TNM stages(P=0.005,P<0.001,and P<0.001,respectively) and with cervical lymph node metastasis(P≤0.001 for all).Meanwhile,Caveolin-1 ex-pression had a negative correlation with GPR30(rs=-0.528,P<0.001) and Vimentin(rs=-0.572,P<0.001).GPR30 and Vimentin expression were positively correlated ( rs=0.812, P<0.001 ).Caveolin-1 under-expression was accompanied by GPR30 or Vimentin over-expression had stronger correlation with LNM ( P=0.020 for Caveolin-1/GPR30 and P=0.001 Caveolin-1/Vimentin ) than did each alone;concomitant high expression of GPR30 and Vimentin had stronger correlation with LNM( P=0.005 for GPR30/Vimentin) than did each alone.And lower expression of Caveolin-1 accompanied by higher expression of GPR30 and Vimentin was significantly as-sociated with LNM as compared with cases not showing such expressing(P<0.001).Conclusion:These results demonstrated that the evaluation of Caveolin-1 ,GPR30 and Vimentin expression may be play an important role in the development and metastasis of PTC,and their biological function may relate with each other.关键词
甲状腺乳头状癌/Caveolin-1/GPR30/VimentinKey words
Papillary thyroid carcinoma/Caveolin-1/GPR30/Vimentin分类
医药卫生引用本文复制引用
赵乐,唐萃,杨磊,莫小梅,朱平,刘智敏..Caveolin-1、GPR30和 Vimentin 在甲状腺乳头状癌组织中的表达及意义[J].中国免疫学杂志,2015,(11):1510-1514,1519,6.基金项目
本文受国家自然科学基金面上项目（81272937）资助。 （）
