中国全科医学Issue(30)：3653-3656,4.DOI:10.3969/j.issn.1007-9572.2015.30.004
胰岛素抵抗及肥胖对中老年女性甲状腺结节的影响研究
Influence of Insulin Resistance and Obesity on Thyroid Nodules in Middle-aged and Old Women
摘要
Abstract
Objective To investigate insulin resistance and different obesity measurement indexes on thyroid nodules in middle-aged and old women.Methods Enrolled 1 507 in-service or retired healthy female employees of a petrochemical enterprise in Ningbo who were no younger than 45 years old and received physical examination in the Hospital of Zhenhai Refine -Chemical Company in Ningbo from March to October in 2013.According to the results of ultrasonic examination , the patients were divided into two groups: thyroid nodule group (n=837) and control group (n=670) .Recorded age, waistline, BMI, SBP, DBP, blood lipid, thyroid function, HbA1c, FBG and FINS.We also calculated HOMA-IR according to FBG and FINS, and the relation between different obesity measurement indexes and the prevalence of thyroid nodules and HOMA-IR was evaluated.Results Among 1 507 subjects, 837 had thyroid nodules with a prevalence of 55.5%.Thyroid nodule group was higher (P<0.05) than normal group in age, waistline, BMI, SBP, DBP, TC, TG, LDL-C, TSH, HbA1c, FBG, FINS and HOMA-IR.With the increase of BMI , there was an increase ( P <0.05 ) in the prevalence of thyroid nodule and HOMA-IR.Central obesity group was higher (P<0.05) than non-central obesity group in the prevalence of thyroid nodule and HOMA-IR.With the increase of HOMA-IR, there was an increase in the prevalence of thyroid nodule (χ2trend =17.257, P<0.001).The multivariate unconditional Logistic regression analysis showed that age 〔OR=1.06, 95%CI (1.04, 1.07)〕, overweight 〔OR =1.39, 95%CI ( 1.05, 1.86 )〕, obesity 〔OR =1.83, 95%CI ( 1.07, 3.12 )〕, TG 〔OR =1.18, 95%CI (1.00, 1.39)〕, TSH 〔OR=0.93, 95%CI (0.86, 1.00)〕, FBG 〔OR=1.37, 95%CI (1.15, 1.64)〕, FINS〔OR =0.94, 95%CI (0.89, 0.99)〕, HOMA-IR 1.2 -1.7 〔OR=1.57, 95%CI (1.12, 2.19)〕 and HOMA-IR≥1.8 〔OR =1.76, 95%CI (1.08, 2.83)〕 had regression relation with the prevalence of thyroid nodules.Conclusion The prevalence of thyroid nodule is high among middle -aged and old women and is closely related with age , blood lipid, thyroid function, FBG and FINS.Overweight, obesity, HOMA-IR may be a risk factor for thyroid nodules.关键词
甲状腺结节/胰岛素抵抗/肥胖症Key words
Thyroid nodule/Insulin resistance/Obesity分类
医药卫生引用本文复制引用
陈长喜,朱忠伟,杜娟,徐益敏,李静,毛玉山..胰岛素抵抗及肥胖对中老年女性甲状腺结节的影响研究[J].中国全科医学,2015,(30):3653-3656,4.基金项目
宁波市科技计划项目 （）
