中国全科医学Issue(30)：3732-3735,4.DOI:10.3969/j.issn.1007-9572.2015.30.021
妊娠早期基于游离胎儿细胞 DNA 检测非整倍性染色体的研究进展
Research Progress of Aneuploidy Detection Based on Cell -free Fetal DNA in the First Trimster of Pregnancy
摘要
Abstract
Aneuploidiy is a major cause for perinatal morbidity and mortality.In the first trimester of pregnancy , the main purpose of prenatal screening method is to achieve maximum detection rate and low false positive rate , and reduce unnecessary invasive procedures at a relatively low cost.Besides the serology , ultrasound and comprehensive screening method , the non-invasive gene detection method using cell -free fetal DNA (cffDNA) in maternal plasma is more rapid and accurate.In this paper , we reviewed the research progress of detection method for aneuploid chromosome abnormality , in order to effectively control the birth of infants with chromosome abnormalities and to provide technical support for the improvement of population quality.关键词
产前诊断/染色体畸变/无创产前DNA检测/游离胎儿细胞DNAKey words
Prenatal diagnosis/Chromosome aberrations/Non-invasive prenatal testing/Cell-free fetal DNA分类
医药卫生引用本文复制引用
马冬,佟文秀,张艳梅,姜杰,李琪,李鸥..妊娠早期基于游离胎儿细胞 DNA 检测非整倍性染色体的研究进展[J].中国全科医学,2015,(30):3732-3735,4.基金项目
河北省自然科学基金资助项目 （）
