中国全科医学Issue(32)：3939-3943,5.DOI:10.3969/j.issn.1007-9572.2015.32.011
锰超氧化物歧化酶基因 rs4880位点多态性与2型糖尿病发生及认知功能的相关性研究
Relationship Between MnSOD -rs4880 Polymorphism and the Development of Type 2 Diabetes as Well as Cognitive Function
摘要
Abstract
Objective To investigate the relationship between Manganese superoxide dismutase(MnSOD) - rs4880 polymorphism and the development of type 2 diabetes(T2DM)as well as cognitive function. Methods We enrolled 450 T2DM patients who were hospitalized in Tangshan Gongren Hospital from March 2008 to March 2010 as the case group,and we enrolled another 512 persons without T2DM that were recruited from a community in Beijing in the same period as the control group. We collected the clinical phenotype data including FPG,TG,TC,HDL - C and LDL - C. The Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)was applied to assess the cognitive function of the subjects,and RFLP - PCR was used to detect MnSOD - rs4880 polymorphism. Results MnSOD - rs4880 has three genotypes:TT,CT and CC. There was no significant difference both in distribution of genotype and allele frequency between the two groups(P ﹥ 0. 05). Significant difference was found in genotype distribution of this site in female subjects between the two groups(P ﹤ 0. 05);subjects with CT genotype had 2. 188 times higher risk to develop T2DM than TT genotype carriers〔95% CI(1. 413,3. 388)〕. Significant difference was also found in allele frequency of rs4880 site in female subjects between the two groups(P ﹤ 0. 05);subjects who carried C allele had 1. 926 times higher risk to develop T2DM than T allele carriers〔95% CI(1. 310,2. 830)〕. There was no significant difference both in the distribution of genotype and allele frequency of rs4880 site in male subjects between the two groups(P ﹥ 0. 05). Association was found between rs4880 site polymorphism and TC,LDL - C and HOMA - IR(P ﹤ 0. 05), while no association was found between rs4880 site polymorphism and FPG,TG and HDL - C( P ﹥ 0. 05). The rs4880 site polymorphism was found associated with RBANS delayed memory(P ﹤ 0. 05),while no association was found between MnSOD- rs4880 polymorphism and immediate memory,visuospatial/ constructional,language,attention and the total score( P ﹥0. 05). Conclusion CT and C are risk genotype and allele for females to develop T2DM,and MnSOD - rs4880 polymorphism is associated with RBANS delayed memory score of T2DM patients.关键词
糖尿病,2 型/锰超氧化物歧化酶/rs4880 位点/多态性,单核苷酸/重复性成套神经心理状态测验量表/认知障碍Key words
Diabetes mellitus,type 2/Manganese superoxide dismutase/rs4880 site/Polymorphism,single nucleotide/RBANS/Cognition disorders分类
医药卫生引用本文复制引用
甄艳凤,周蕾,刘兴宇,房辉,徐刚,杨岳,孙雪玲,张谷月,张丹丹,许静..锰超氧化物歧化酶基因 rs4880位点多态性与2型糖尿病发生及认知功能的相关性研究[J].中国全科医学,2015,(32):3939-3943,5.基金项目
河北省自然科学基金资助项目 （）
