摘要
Abstract
Objective To investigate lipid metabolism and serum angiogenin 2(ANG2)level in patients with chronic obstructive pulmonary disease( COPD) and their relationship with illness severity. Methods Using convenience number table method,we enrolled 185 COPD patients who were admitted into Hebei General Hospital from November 2012 to January 2014. We also enrolled 30 healthy people who received physical examination in the same period in the hospital as control group. COPD group was administrated with inhalation powder of salmeterol and fluticasone propionate combined with tiotropium bromide. Fasting venous blood was taken on the next day after the inclusion from control group and was taken before treatment(T0),after 1-week treatment(T1),2-week treatment(T2),1 -month treatment(T3)and 3 -month treatment(T4)from COPD group. Then serum ANG2 level,TC,TG,HDL-C and LDL-C were detected,and BODE indexes were evaluated. Blood lipid level and serum ANG2 level were compared among COPD patients with different BODE index grades before and after treatment,and relationship between dyslipidemia and serum ANG2 level of the patients and BODE index. Results COPD group and control group were not significantly different in the levels of HDL-C and LDL-C( P﹥0. 05 for all);COPD group and control group were significantly different in the levels of TC,TG and ANG2 and BODE indexes( P﹤0. 05 for all);in COPD group,the levels of TC and TG at T2,T3 and T4 were higher than those of T0(P﹤0. 05),and the ANG2 level and BODE index of T2,T3 and T4 were lower than those of T0(P﹤0. 05);control group was higher in the levels of TC and TG and were lower in ANG2 level and BODE index than COPD group at T0 ,T1 ,T2 ,T3 and T4 ( P﹤0. 05 for all). There were significant differences in the BODE index grading distribution between T0 and T4(U =9. 25,P ﹤0. 01). At T0 and T4,patients with different BODE index grades were not significantly different in the levels of HDL-C and LDL-C( P﹥0. 05 for all);patients with different BODE index grades were significantly different in the levels of TC,TG and ANG2( P ﹤0. 05 for all);higher BODE index grades were associated with lower levels of TC and TG and higher ANG2 level ( P ﹤0. 05 for all ). Pearson correlation analysis showed that the levels of TC and TG of COPD patients were negatively correlated with BODE index ( r= -0. 941,-0. 940,P﹤0. 05),and were positively correlated with serum ANG2 level and BODE index( r=0. 921,P﹤0. 05). The adverse responses during the treatment of COPD patients were all slight and disappeared within 3 days without intervention. Conclusion Patients with COPD has disorder of lipid metabolism and high serum ANG2 level,and the blood lipid level and the level of serum ANG2 are related to their illness severity. It may be related with endothelial cell apoptosis and vascular degeneration induced by ANG2 combining with Tie receptors and lower blood lipid level induced by malnutrition in patients with COPD,thus lipid metabolism and serum ANG2 of COPD patients can be used as reference indicators for their illness severity.关键词
肺疾病,慢性阻塞性/脂代谢/促血管生成素2/病情严重程度Key words
Pulmonary disease,chronic obstructive/Lipid metabolism/Angiogenin 2/Severity of illness分类
医药卫生
