中国实验动物学报2015，Vol.23Issue(5)：506-508,512,4.DOI:10.3969/j.issn.1005-4847.2015.05.012
大鼠局灶性脑缺血模型评价方法间关联性分析
Analysis of the correlation between three evaluation methods of rat models of focal cerebral ischemia/reperfusion
摘要
Abstract
Objective To analyze the correlation between three evaluation methods of middle cerebral artery occlu -sion and focal cerebral ischemia , and to explore a new method and standard for the evaluation of the model .Method Thirty healthy adult male SD rats were randomly divided into a sham-operated group ( n=20 ) and model group .According to Zea-Longa procedure ,we established the disease model to detect the changes in cerebral blood flow before and after sur -gery.The resulted cerebral infarction area was taken as gold standards .Then we analyzed the correlation between the standards and the changes in cerebral blood flow .Results The changes of infarction area ratio were positively correlated with the changes of cerebral blood flow in the model rats .Conclusions The changes of rat cerebral blood flow can be used to evaluate whether the cerebral ischemia model is successful or not .关键词
脑梗死面积率/行为学评分/脑血流量/大鼠Key words
Infarct area/Behavioral score/Cerebral blood flow/Rats分类
生物科学引用本文复制引用
崔煦然,刘钊,张志斌,钟菊迎..大鼠局灶性脑缺血模型评价方法间关联性分析[J].中国实验动物学报,2015,23(5):506-508,512,4.基金项目
中国中医科学院院自主课题( ZZ2012012 ). （ ZZ2012012 ）
