中国比较医学杂志Issue(9)：8-13,38,7.DOI:10.3969/j.issn.1671.7856.2015.009.002
Lewis 大鼠肾阳虚体质及其 HPA 轴功能失衡
Kidney yang deficiency constitution and hypothalamic-pituitary-adrenal axis dysfunction in Lewis rats
摘要
Abstract
ObjectiveToinvestigatethekidneyyangdeficiencyconstitutionandhypothalamus-pituitary-adrenal ( HPA) axis dysfunction in Lewis rats .Method Two kidney yang deficiency models were established by subcutaneous injection of hydrocortisone and by adrenalectomy to induce hypothalamic -pituitary-adrenal ( HPA) axis dysfunction in Lewis rats.Wistar rats were used as control and compared with the two types of Lewis rat models of kidney yang deficiency .The degree of kidney yang deficiency of the Lewis rats was evaluated by examination and detection of the general signs , behavior , and neuroendocrine function , and so on .Result Compared with the normal Wistar rats , the body weight of Lewis rats was significantly higher than that of Wistar rats at the same age .The body temperature , urine volume and grip strength were significantly lower than those of Wistar rats ( P<0.01 for all ) .The memory ability of the Lewis rats was slightly decreased.The liver, kidney and adrenal indexes were significantly decreased in the Lewis rats (P<0.01).The levels of serum ACTH, CRH, cGMP, Cort and urine 17OHCS were significantly decreased (P<0.01).Conclusion A very slight deficiency of adrenal cortex function of Lewis rats is caused by genetic inheritance , and Lewis rats have the constitution of congenital kidney yang deficiency ( criticality or prophase of kidney yang deficiency ) .关键词
Lewis大鼠/肾阳虚体质/HPA轴功能失衡Key words
Lewis rat/Wistar rat/Kidney yang deficienc , Hypothalamus-pituitary-adrenal dysfunction分类
医药卫生引用本文复制引用
寿旗扬,张利棕,蔡月琴,方鹏,倪琳慧,徐剑钦,盛佳萍,方明笋,陈民利..Lewis 大鼠肾阳虚体质及其 HPA 轴功能失衡[J].中国比较医学杂志,2015,(9):8-13,38,7.基金项目
浙江省公益性技术应用研究计划（2015C37091）；国家自然科学基金项目（81202972）；浙江中医药大学校级科技创新团队（XTD201301）；国家级大学生创新创业训练计划项目（201310344001）。 （）
