中国动物传染病学报Issue(4)：65-71,7.
应激颗粒和抗病毒先天性免疫
STRESS GRANULE AND ANTIVIRAL INNATE IMMUNITY
摘要
Abstract
In the course of virus infection, virus genome and protein produced by virus replication initiate innate immunity signaling pathway, leading to interferon secretion and interferon stimulate gene expression and ultimately establish an antiviral state. Meanwhile, virus infection also induced stress granule (SG) containing ribonucleoprotein, RNA binding protein and eukaryotic initiated factors, etc. Innate immunity and SG are both cellular antiviral response. Correspondingly, virus promotes its own replication through inhibit SG forma-tion and innate immunity. SG contains RNA binding protein and a series of virus or host RNA, while the molecular associated to innate immunity such as pattern recognition receptor also specifically recognize virus RNA, indicating their close relationship. This review will focus on the strategies how SG and innate immunity collaboratively exert antiviral function.关键词
应激颗粒/病毒/先天性免疫/RNA结合蛋白Key words
Stress granule/virus/innate immunity/RNA binding protein分类
农业科技引用本文复制引用
董路娜,孙英杰,郑航,胡桂学,丁铲..应激颗粒和抗病毒先天性免疫[J].中国动物传染病学报,2015,(4):65-71,7.基金项目
国家自然科学基金青年基金（31400144）；上海市青年科技英才杨帆计划（14YF1408000）；中国博士后科学基金面上一等资助 （）
