中国药科大学学报Issue(5)：541-547,7.DOI:10.11665/j.issn.1000-5048.20150504
转录因子 DEC1在肿瘤发生发展过程中的作用
Role of transcription factor DEC1 in the initiation and progression of malignant tumors
摘要
Abstract
DEC1 is a basic helix-loop-helix(bHLH)transcription factor involved in the regulation of cell prolif-eration;cell differentiation;lymphocytes maturation;circadian rhythms;immune response and response to hypoxia.Recent studies have revealed that the expression of DEC1 is abnormally high in various tumor tissues and cells.In addition;the expression of DEC1 in the tumor tissue is related to the malignancy of various cancer types.This paper;therefore;focuses on the relationship between DEC1 and proliferation;apoptosis;cellular senes-cence;invasion and metastasis of tumor cells;in order to elaborate the role of DEC1 in the pathogenesis and pro-gression of tumor.关键词
转录因子/DEC1/增殖/凋亡/侵袭转移/细胞衰老Key words
transcription factor/DEC1/proliferation/apoptosis/invasion and metastasis/cellular senescence分类
医药卫生引用本文复制引用
杨欢,熊晶,洛文靖,奚涛..转录因子 DEC1在肿瘤发生发展过程中的作用[J].中国药科大学学报,2015,(5):541-547,7.基金项目
国家自然科学基金资助项目（No.81302855）；江苏省自然科学基金资助项目（No.BK2012446）This study was supported by the National Natural Science Foundation of China牗No.81302855牘and the Natural Science Foundation of Jiangsu Province牗No.BK2012446牘 （）
