中国药科大学学报Issue(5)：575-578,4.DOI:10.11665/j.issn.1000-5048.20150510
达沙替尼原料药的晶型分析
Crystal form identification of dasatinib in tablets
汪建明 1陈砚美 1张海禄 2张炎锋 1陈敏华1
作者信息
- 1. 苏州晶云药物科技有限公司，苏州215123
- 2. 中国科学院苏州纳米技术与纳米仿生研究所，核磁共振波谱与影像实验室，苏州215123
- 折叠
摘要
Abstract
The aim of this study was to establish the methods to identify crystal form of dasatinib in tablets.X-ray powder diffraction(XRPD)and solid-state nuclear magnetic resonance(ssNMR)were used to analyze the crystal form of dasatinib in Sprycel® tablets and Yinishu® tablets.The results showed that monohydrate and anhydrate were identified in Sprycel® and Yinishu® tablets respectively;with no detectable anhydrate in Sprycel® tablets and no detectable monohydrate in Yinishu® tablets.The results of XRPD and ssNMR were consistent;and could be both applied in the crystal form identification of dasatinib in tablets.关键词
达沙替尼/多晶型/X射线粉末衍射/固态核磁共振/晶型分析Key words
dasatinib/polymorph/X-ray powder diffraction/solid-state nuclear magnetic resonance/crystal form identification分类
医药卫生引用本文复制引用
汪建明,陈砚美,张海禄,张炎锋,陈敏华..达沙替尼原料药的晶型分析[J].中国药科大学学报,2015,(5):575-578,4.
