中国药房Issue(27)：3786-3788,3.DOI:10.6039/j.issn.1001-0408.2015.27.16
昂丹司琼对腰-硬联合麻醉剖宫产术中麻醉效果的影响
Effect of Ondansetron on the Anesthesia of Spinal-epidural Anesthesia in Cesarean Section Surgery
郭丁伟 1方海阳 1陈英英1
作者信息
- 1. 浙江洞头县人民医院麻醉科，浙江洞头 325700
- 折叠
摘要
Abstract
OBJECTIVE:To observe the effect of ondansetron on the anesthesia of cesarean section surgery with spinal-epidur-al anesthesia. METHODS:A total of 60 singletons full-term pregnancy were randomly divided into test group and control group. Test group was given 6% Hetastarch(130/0.4)electrolyte injection 500 ml by intravenous infusion 30 min before anesthesia,and Ondansetreon hydrochloric acid injection 4 ml by intravenous infusion 5 min before anesthesia;control group was given 6% Hetas-tarch(130/0.4)electrolyte injection 500 ml by intravenous infusion 30 min before anesthesia,and 0.9% Sodium chloride injection 4 ml by intravenous infusion 5 min before anesthesia. The clinic data was recorded,including the mean arterial pressure (MAP) and heart rate(HR)before anesthesia puncture(T1),after anesthesia maternal left side(T2),after fetal childbirth(T3)and at the end of surgery(T4),Apgar score and incidence of adverse reactions. RESULTS:MAP in control group at T2,T3 was obviously low-er than T1 and test group,HR was obviously higher than T1 and test group,the difference was statistically significant(P<0.05);there were no significant differences in the MAP and HR in test group at each time point(P>0.05). Apgar score of newborn after 1 min birth in test group was significantly higher than control group,the difference was statistically significant (P<0.05),and there was no significant difference in the Apgar score of newborn after 5 min birth between 2 groups(P>0.05). The ADR incidence in test group was significantly lower than control group(P<0.05). CONCLUSIONS:Ondansetron can effectively reduce the inci-dences of vomit vomitting and hypotension in on the cesarean section surgery with spinal-epidural anesthesia,with good safety.关键词
腰-硬联合麻醉/剖宫产/昂丹司琼/羟乙基淀粉Key words
Spinal-epidural anesthesia/Cesarean section/Ondansetron/Hetastarch分类
医药卫生引用本文复制引用
郭丁伟,方海阳,陈英英..昂丹司琼对腰-硬联合麻醉剖宫产术中麻醉效果的影响[J].中国药房,2015,(27):3786-3788,3.
