中国药房Issue(27)：3864-3866,3.DOI:10.6039/j.issn.1001-0408.2015.27.43
丹珍头痛胶囊的HPLC指纹图谱研究
Study on the HPLC Fingerprint Chromatogram of Danzhen Headache Capsules
张宇霞 1昝占全 2王统霞 3李春梅 1纪兰菊1
作者信息
- 1. 青海益欣药业有限责任公司，西宁 810003
- 2. 中国科学院西北高原生物研究所/中国科学院藏药研究重点实验室，西宁 810001
- 3. 中国科学院大学生命科学学院，北京100049
- 折叠
摘要
Abstract
OBJECTIVE:To establish the HPLC fingerprint chromatogram of Danzhen headache capsules. METHODS:HPLC method was adopted. The column was Dikma Diamonsil C18 with the mobile phase of methanol-acetonitrile-water(gradient elution) at the flow rate of 1.0 ml/min;the temperature was 40 ℃,the detection wavelength was 340 nm,the sample size was 20 μl and the detection time was 65 min. RESULTS:RSDs of precision,stability and reproducibility tests were no more than 0.23%;13 com-mon peaks were identified in 10 batches of Danzhen headache capsules and the similarity of all samples were higher than 0.90. CONCLUSIONS:The method is simple,accurate and reproducible,and can be used for the process stability evaluation and quali-ty control of Danzhen headache capsules.关键词
丹珍头痛胶囊/高效液相色谱法/指纹图谱/相似度Key words
Danzhen headache capsules/HPLC/Fingerprint chromatogram/Similarity分类
医药卫生引用本文复制引用
张宇霞,昝占全,王统霞,李春梅,纪兰菊..丹珍头痛胶囊的HPLC指纹图谱研究[J].中国药房,2015,(27):3864-3866,3.
