中国药房Issue(28)：3957-3959,3960,4.DOI:10.6039/j.issn.1001-0408.2015.28.23
模糊综合评价法在处方筛选中的应用研究Δ
Application of Fuzzy Comprehensive Evaluation in Formulation Screening
摘要
Abstract
OBJECTIVE:To investigate the application of fuzzy comprehensive evaluation in formulation screening. METH-ODS:Taking Compound paracetamol and chlorphenamine maleate granules as model drug,based on single factor experiment,L9(34) orthogonal test was used to screen the formulation with the amount of aspartame,hawthorn powder essence,milk powder essence and saccharose as factors,using dissolution rate of caffeine as index. The granules prepared by 9 kinds of formulation in orthogonal test were evaluated with fuzzy comprehensive evaluation in terms of taste,aroma,color and dissolubility. The optimized formula-tion was validated and compared with original formulation. RESULTS:The formulation 5 was the optimal choice in both orthogo-nal test and fuzzy comprehensive evaluation,and obtained same results. Compared with sensory comprehensive score (63.12) and dissolution rate of caffeine (91.3%) in original formulation,two indicators of optimized formulation in 3 tests were 84.00 and 99.07% in average (RSD<2.0%,n=3). CONCLUSIONS:Fuzzy comprehensive evaluation can be used for the formulation screening of sensory evaluation index. It is scientific and accurate.关键词
模糊综合评价法/复方氨酚那敏颗粒/感官评价/正交试验Key words
Fuzzy comprehensive evaluation/Compound paracetamol and chlorphenamine maleate granules/Sensory evaluation/Orthogonal test分类
医药卫生引用本文复制引用
李龙龙,郝鹏彬,王文鹏,冯玉康,屈云萍,姜国志,李振江..模糊综合评价法在处方筛选中的应用研究Δ[J].中国药房,2015,(28):3957-3959,3960,4.基金项目
国家科技重大专项石家庄高端医药产业园区创新药物孵化基地项目 （）
