中国药房Issue(29)：4082-4085,4086,5.DOI:10.6039/j.issn.1001-0408.2015.29.17
药源性横纹肌溶解症高危因素研究
Causative Study of Drug-induced Rhabdomyolysis
姜玲海 1张军 1方忠宏 1周泉2
作者信息
- 1. 复旦大学附属金山医院药剂科，上海 201508
- 2. 上海市食品药品监督管理局金山分局，上海 200540
- 折叠
摘要
Abstract
OBJECTIVE:To investigate and analyze the causative factors and characteristics of drug-induced rhabdomyolysis in China,in order to reduce the incidence of rhabdomyolysis. METHODS:Search all cases of rhabdomyolysis in China Knowledge Re-source Integrated Database from Jan 1975 to Jun 2014. Sex,age,disease history,drugs administered,drug combination,clinical presentation and outcome of rhabdomyolysis were censused and analyzed. RESULTS:There were altogether 185 rhabdomyolysis cas-es reported,of which 57.8% were over 60 years old ,78.9% were induced by lipid regulators,and 55.7% were by statins;74.1%occurred within 1 month after drug administration,and 86.6% became normal within 1 month when causative drugs discontinued or with treatment;and 4.9% died. CONCLUSIONS:Eldly,complicated with multi-factors,such as multiple organ dysfunction syn-drome,irrational drug combination and over-doses,especially with lipid regulators,are important causative factors of rhabdomyoly-sis. Individualized administration of drugs and prescription as less as possible should be recommended to reduce the incidence of rhabdomyolysis.关键词
横纹肌溶解症/调节血脂药/他汀类药/多系统疾病Key words
Rhabdomyolysis/Lipid regulators/Statins/Multiple organ dysfunction syndrome分类
医药卫生引用本文复制引用
姜玲海,张军,方忠宏,周泉..药源性横纹肌溶解症高危因素研究[J].中国药房,2015,(29):4082-4085,4086,5.
