摘要
Abstract
OBJECTIVE:To observe therapeutic efficacy and safety of Calcipotriol betamethasone ointment combined with Compound glycyrrhizin injection in the treatment of erythrodermic psoriasis. METHODS:120 cases of erythrodermic psoriasis were randomly divided into observation group and control group,60 cases in each. Control group received Calcipotriol betamethasone ointment topical,2 times a day,for 6 weeks. Observation group was additionally given Compound glycyrrhizin injection 80 ml add-ed into 250 ml Glucose solution intravenously,once a day,on the basis of control group. PASI score,VAS score,DLQI score, Clinical efficacy and ADR of 2 groups were observed. RESULTS:Two groups of patients after treatment,PASI score,VAS score, lesion area and DLQI score were significantly decreased,the observation group decreased more significantly,the difference was sta-tistically significant (P<0.05). The total effective rate of observation group (91.7%) was higher than that of control group (80.0%),with statistical significance(P<0.05);there was no statistical significance in the incidence of ADR between observa-tion group (18.3%)and control group(15.0%)(P>0.05). CONCLUSIONS:Calcipotriol betamethasone ointment combined with Compound glycyrrhizin injection can effectively alleviate the clinical symptoms of psoriasis erythrodermic,improve their quality of life,has a definite curative effect and ADR.关键词
钙泊三醇倍他米松软膏/复方甘草酸苷注射液/红皮型银屑病/不良反应Key words
Calcipotriol betamethasone ointment/Compound glycyrrhizin injection/Erythrodermic psoriasis/Safety分类
医药卫生
