中国药房Issue(30)：4213-4214,4215,3.DOI:10.6039/j.issn.1001-0408.2015.30.13
卡马西平联合托吡酯治疗部分性癫痫的临床观察
Clinical Observation of Carbamazepine Combined with Topiramate in the Treatment of Partial Epilepsy
罗云波 1彭思璐 2许学杰 3唐兴江3
作者信息
- 1. 四川医科大学临床医学院，四川泸州 646000
- 2. 四川绵阳四〇四医院神经内科，四川绵阳 621000
- 3. 四川绵阳四〇四医院神经内科，四川绵阳 621000
- 折叠
摘要
Abstract
OBJECTIVE:To observe the efficacy and safety of carbamazepine combined with topiramate in the treatment of par-tial epilepsy. METHODS:130 patients with partial epilepsy were randomly divided into observation group and control group. Con-trol group was orally treaed with carbamazepine 100 mg,3 times a day. Based on the treatment of control group,observation group was orally treaed with topiramate initial dose of 25 mg,once a day,and then increased 25 mg every week,the maximum dose was no more than 200 mg,once a day. After 6 months,the efficacy was evaluated,frequency of epileptic seizures,EEG epileptiform discharges wave and incidence of adverse reactions were observed. RESULTS:The total effective rate in observation group was sig-nificantly higher than control group(P<0.05). After treatment,the frequencies of epileptic seizures in 2 groups were significantly lower than before,6 months<3 months<1 month,and observation group was lower than control group(P<0.05).The EEG epilep-tiform discharges wave were in observation significantly better than control group(P<0.05). There were no significant differences incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Carbamazepine combined with topiramate has better efficacy than carbamazepine alone in the treatment of partial epilepsy,with similar safety.关键词
卡马西平/托吡酯/部分性癫痫/发作频率Key words
Carbamazepine/Topiramate/Partial epilepsy/Seizure frequency分类
医药卫生引用本文复制引用
罗云波,彭思璐,许学杰,唐兴江..卡马西平联合托吡酯治疗部分性癫痫的临床观察[J].中国药房,2015,(30):4213-4214,4215,3.
