中国药房Issue(32)：4529-4531,3.DOI:10.6039/j.issn.1001-0408.2015.32.23
右美托咪定辅助全麻对患者心脑缺血再灌注损伤的保护作用
Protective Effects of Adjuvant General Anesthesia of Dexmedetomidine on Cardiac and Cerebral Isch-emia-perfusion Injury
摘要
Abstract
OBJECTIVE:To investigate the protective effects of adjunctive general anesthesia of dexmedetomidine on cardiac and cerebral ischemia-perfusion injury. METHODS:50 patients,ASA physical status Ⅰ-Ⅱ,undergoing selective tracheal intuba-tion,were randomly divided into dexmedetomidine group (group D) and control group (group C) with 25 cases in each group. The patients in group D received a loading dose of 1 μg/kg of dexmedetomidine by infusion pump before anaesthesia,10 min lat-er by a maintenance dose of 0.5 μg/(kg·h)till the end of surgery;whereas patients in group C received normal saline and same induction. HR,SBP and DBP of 2 groups were monitored at the beginning of operation,10 min after incision,30 min after inci-sion,at the end of operation. Blood samples of vena jugularis interna were taken to determine the plasma levels of cardiac tropo-ninⅠ(cTnⅠ) ,adrenaline and norepinephrine before anesthesia induction (T0),at the end of surgery (T1),6 h after surgery (T2),12 h after surgery(T3),24 h after surgery(T4),48 h after surgery(T5). RESULTS:There was no statistical significance in the levels of HR,SBP and DBP in group D between during operation and at the beginning of operation(P>0.05);those in-dex were significantly lower than those of group C at corresponding time points,with statistical significance(P<0.05). The lev-els of cTnⅠ in group D at T2-T5 were significantly lower than in group C,with statistical significance(P<0.05). The levels of adrenaline and norepinephrine at T1-T5 were significantly lower than group C,with statistical significance (P<0.05). CONCLU-SIONS:Adjunctive general anesthesia of dexmedetomidline can improve cardiac and cerebral ischemia-perfusion injury to certain extent.关键词
右美托咪定/缺血再灌注损伤/心肌肌钙蛋白Ⅰ/肾上腺素/去甲肾上腺素Key words
Dexmedetomidine/Ischemia-perfusion injury/Cardiac troponinⅠ/Adrenaline/Norepinephrine分类
医药卫生引用本文复制引用
黄厚刚,罗红霞..右美托咪定辅助全麻对患者心脑缺血再灌注损伤的保护作用[J].中国药房,2015,(32):4529-4531,3.基金项目
重庆市永川区科技计划项目 （）
