中国药房2015，Vol.26Issue(33)：4634-4636,3.DOI:10.6039/j.issn.1001-0408.2015.33.09
某三甲医院心内科CYP3A4抑制剂与阿托伐他汀或辛伐他汀联用情况分析
Analysis of the Combination Use of CYP3A4 Inhibitors with Simvastatin or Atorvastatin in the Cardiology De-partment of A Third-grade Class A Hospital
王清理 1王晓慧 1卫永丽 1陈雪平 1贾明璐 1裴媛1
作者信息
- 1. 漯河市中心医院药学部,河南漯河 462000
- 折叠
摘要
Abstract
OBJECTIVE:To provide reference for strengthening the safety of the combination use of CYP3A4 inhibitors with statins in clinical treatment. METHODS:30 cases per month(totally 300 cases)(the hospitalization time was more than 10 days) discharged from the cardiology department of a third-level class A hospital during Jan. to Oct. 2013 were selected randomly,and statistical analysis was made into general information of patients,whether to use statins and CYP3A4 inhibitor,and whether to monitor safety indicators of liver and kidney function and creatine kinase. RESULTS:Totally 291 patients were treated with statins with a total use rate of 97%,including 265 cases of atorvastatin and 11 cases of simvastatin. The CYP3A4 inhibitors were com-bined with amlodipine,diltiazem,verapammy,amiodarone,Ginkgo biloba leaf,fenofibrate and clarithromycin,etc.,and 162 (59%) patients were given the combination use of simvastatin or atorvastatin with CYP3A4 inhibitors. But the liver and kidney function,creatine kinase and other safety indicators were not monitored by laboratory examination during medication. CONCLU-SIONS:Atorvastatin and simvastatin are used commonly in patients with cardiovascular disease,and the combination use rate with CYP3A4 inhibitor is relatively higher and needs long-term medication,drug dosage should be limited according to the direction of instructions and the adverse reactions induced by drug interactions should be noticed to strengthen medication monitor and education for patients.关键词
阿托伐他汀/辛伐他汀/CYP3A4抑制剂/联合用药/药物相互作用Key words
Atorvastatin/Simvastatin/CYP3A4 inhibitor/Combination use/Drug interaction分类
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王清理,王晓慧,卫永丽,陈雪平,贾明璐,裴媛..某三甲医院心内科CYP3A4抑制剂与阿托伐他汀或辛伐他汀联用情况分析[J].中国药房,2015,26(33):4634-4636,3.
