中国药房Issue(34)：4801-4803,3.DOI:10.6039/j.issn.1001-0408.2015.34.16
复方葛根片对D-半乳糖致衰老模型大鼠心肌的保护作用
Study on Protective Effect of Compound Pueraria Tablets on Myocardium of Aging Model Rats Induced by D-galactose
陶利 1王玉娟 1毕云生 1张淑瑜 1于燕莉1
作者信息
- 1. 济南军区总医院药剂科，济南 250031
- 折叠
摘要
Abstract
OBJECTIVE:To study the protective effect of Compound pueraria tablets on the aging model rats. METHODS:The rats were divided into normal group,model control group,positive control group (vitamin E) and Compond pueraria tablets high-dose,medium-dose and low-dose (800,400,200 mg/kg) groups. The aging model rats were made by injection of D-galac-tose solution for 30 d in latter 5 groups,and they were given relevant medicine at same time every 7 days for consecutive 56 days since 31st day. SOD activity and MDA content in the serum and myocardium and LPF contents in the myocardium were determined after the last dosing,and apoptotic cells were counted and the pathology of cerebral tissues were observed. RESULTS:Compared with normal group,the activity of SOD in the serum and myocardium were decreased significantly in model control group,MDA and LPF contents in the myocardium and the number of apoptotic cells were increased significantly(P<0.01);significant myocar-dial cell injury was found. Compared with model control group,the activity of SOD in the serum and myocardium were increased significantly,while MDA and LPF content in the myocardium and the number of apoptotic cells in Compound pueraria tablets high-dose,medium-dose and low-dose groups were decreased significantly(P<0.05 or P<0.01);myocardial cell morphology was improved significantly. CONCLUSIONS:Compound pueraria tablets has obvious protective effect on myocardial cells in aging rats induced by D-galactose,the mechanism maybe related to the increase of SOD activity and the decrease of the content of MDA and LPF.关键词
复方葛根片/抗衰老/大鼠/氧化损伤/心肌细胞/病理形态Key words
Compond pueraria tablets/Anti-aging/Rats/Oxidative damage/Myocardium cells/Pathological morphology分类
医药卫生引用本文复制引用
陶利,王玉娟,毕云生,张淑瑜,于燕莉..复方葛根片对D-半乳糖致衰老模型大鼠心肌的保护作用[J].中国药房,2015,(34):4801-4803,3.
