中国药理学通报Issue(11)：1502-1504,1505,4.DOI:10.3969/j.issn.1001-1978.2015.11.006
外侧缰核功能及相关机制研究进展
Progress on functions of lateral habenula and related mechanisms
摘要
Abstract
Lateral habenula ( LHb ) , which is situated in the dorsal diencephalon of all vertebrates, is an important component of the habenular complex. The neural network outlined in previ-ous studies indicates that LHb acts not only as an important relay station to link the forebrain with the midbrain regions that in-volved in regulating behavioral responses to reward and mediating the transmassion of negative feedback information, but also is closely connected with 5-HT system. Indeed, recently studies demonstrate that experimental manipulations of LHb are followed by behavioural alterations in relation to drug addiction, reward-a-version responses, pain, sleep, depression and so on. This arti-cle mainly reviews the mechanisms of LHb involved in all kinds of physiological activities.关键词
外侧缰核/药物成瘾/逃跑回避反应/奖赏-厌恶/抑郁症/疼痛/认知功能与情绪Key words
lateral habenula/drug addiction/behavioral avoid-ance/reward-aversion/depression/pain/cognitive function and emotion分类
医药卫生引用本文复制引用
姚瑞,曹君利..外侧缰核功能及相关机制研究进展[J].中国药理学通报,2015,(11):1502-1504,1505,4.基金项目
国家自然科学基金重点项目( No 81230025) （ No 81230025）
国家自然科学基金面上项目(No 81070888) （No 81070888）
