中国医学创新Issue(5)：11-12,13,3.DOI:10.3969/j.issn.1674-4985.2013.05.006
右美托咪定与咪达唑仑对依托咪酯全麻诱导时肌阵挛影响的对比研究
Comparison of Pretreatment with Dexmedetomidine and Midazolam in Prevention of Myoclonus after Application of Etomidate/KANG
康振明 1谢文钦 1谢文吉 1江长城 1赵桀1
作者信息
- 1. 福建医科大学附属泉州市第一医院 福建 泉州 362000
- 折叠
摘要
Abstract
Objective:To compare the clinical effects of pretreatment with dexmedetomidine and midazolam in prevention of myoclonus after in general anesthesia induction using etomidate. Method:120 elective patients,ASA grade I~II,undergoing gynecology surgery under general anesthesia were randomly allocated to three groups with 40 cases each. Dexmedetomidine Group(n= 40)received dexmedetomidine 0.5μg/kg,Midazolam group(n=40) received midazolam 0.03 mg/kg and control group(n=40)received the same volume normal saline. All the patients were given etomidate(0.3 mg/kg)5 minute after pretreatment. The onset of myoclonus was observed and the severity was recorded. Result:Twenty-two patients(55%)in the control group had myoclonus after etomidate injection compared to 2(5 %)and 3(7.5 %)in the dexmedetomidine and midazolam groups ,respectively(P<0.05). Conclusion:Pretreatment with dexmedetomidine 0.5μg/kg and midazolam 0.03 mg/kg can greatly reduce myoclonus after etomidate induction,and the effects are similar. In view of dexmedetomidine in anesthesia of other,more suitable for the joint of etomidate as an anesthetic induction agents .关键词
右美托咪定/咪达唑仑/依托咪酯/麻醉/全身/肌阵挛Key words
Dexmedetomidine/Midazolam/Etomidate/Anesthesia/General/Myoclonus引用本文复制引用
康振明,谢文钦,谢文吉,江长城,赵桀..右美托咪定与咪达唑仑对依托咪酯全麻诱导时肌阵挛影响的对比研究[J].中国医学创新,2013,(5):11-12,13,3.
