中国医学创新Issue(7)：35-36,2.DOI:10.3969/j.issn.1674-4985.2013.07.019
替米沙坦治疗充血性心力衰竭的疗效及对TNF-α、IL-6的影响
Clinical Study of Telmisartan in Patients with Congestive Heart Failure and Effects of Telmisartan on Plasma TNF-α and IL-6
阮国虎 1刘卫清 2李娟1
作者信息
- 1. 河南省漯河市第二人民医院 河南 漯河 462000
- 2. 河南省人民医院
- 折叠
摘要
Abstract
Objective:To investigate the effects of telmisartan on cardiac function and serum levels of tumor necrosis factor-α(TNF-α), interleukin -6(IL-6)in patients with congestive heart failure(CHF).Method:The levels of serum TNF-α,IL-6 were determined by radioimmunoassay in 106 CHF cases(53 of whom were treated by telmisartan and other 53 were treated by conventional treatment).Result:After 4-week treatment,the NYHA classification and the plasma levels of TNF-α and IL-6 decreased significantly in the telmisartan group(P<0.01),although the clinical efficacy in the candesartan group showed better improvement than the control group,but not reached statistical significant(P>0.05). Conclusion:The efficacy of telmisartan is effective and safe for patients with CHF,and significant reduction of the plasma TNF-α and IL-6 Levels.关键词
心力衰竭/替米沙坦/肿瘤坏死因子α/白细胞介素-6Key words
Heart failure/Telmisartan/Tumor necrosis factor-α/Inter leukin-6引用本文复制引用
阮国虎,刘卫清,李娟..替米沙坦治疗充血性心力衰竭的疗效及对TNF-α、IL-6的影响[J].中国医学创新,2013,(7):35-36,2.
