中国医学创新Issue(12)：9-11,12,4.DOI:10.3969/j.issn.1674-4985.2013.12.004
姜黄素对人宫颈癌细胞株Hela细胞增殖的作用的研究以及p53表达的影响
Effects of Curcumin on Cell Apoptosis and Expression of p53 of Human Cervical Carcinoma cell Line HeLa
摘要
Abstract
Objective:To observe the effect of cuicumin on proliferation of human cervical cancer Hela cells and expression of p53 protein. Method:In this paper,Hela cells were treated with curcumin at various concentrations for various hours,Then determined for proliferation activity by MTT method,for transcription levels ofβ-catenin and p53 mRNAs by RT-PCR,and for expressions ofβ-catenin and p53 protein by Western blot. Result:Curcumin showed dose-and time-dependent inhibitory effect on the proliferation of Hela cells.Meanwhile,curcumin increased the mRNA transcription and protein expression levels ofβ-catenin and p53.Conclusion:Curcumin inhibited the proliferation of Hela cells by a possible mechanism of increased the express of p53.关键词
姜黄素/宫颈癌/p53mRNA/p53蛋白Key words
Curcumin/Cervical cancer/p53mRNA/p53 protein引用本文复制引用
姜智慧,陆晓媛,周健..姜黄素对人宫颈癌细胞株Hela细胞增殖的作用的研究以及p53表达的影响[J].中国医学创新,2013,(12):9-11,12,4.基金项目
江苏省卫生厅康莱特肿瘤基金(编号:P200943) （编号:P200943）
