中国医学创新Issue(16)：1-2,3,3.DOI:10.3969/j.issn.1674-4985.2013.16.001
血清ICAM-1和IL-6水平与肾功能损害的相关性研究
The Correlation between Serum ICAM-1 and IL -6 Levels and the Degree of Renal Function Injury
石海燕 1胡维维 1杨秀媚 1赖均鹏 1刘笑芬1
作者信息
- 1. 广东省佛山市第一人民医院 广东 佛山 528000
- 折叠
摘要
Abstract
Objective:To investigate correlation of serum Intercellular adhesion molecule-1 and Interleukin-6 levels with renal injury, to reveal the clinical value of serum ICAM-1 and IL -6 concentration detection for evaluation of renal function injury.Method:48 subjects were collected, who received renal function injury evaluation from August 2011 to July 2012. ELISA was performed to detect serum ICAM-1 and IL -6 concentration,and semi automatic biochemical analyzer was used to measure serum creatinine concentration, which was used for calculation of glomerular filtration rate ( eGFR ) value. Compared serum ICAM-1 and IL -6 concentrations of subjects with eGFR≥ 90 and eGFR < 90 , and analyzed the correlation between serum ICAM-1 and IL -6 concentrations and eGFR value.Result:Serum ICAM-1 and interleukin -6 concentrations of eGFR < 90 group ( renal injury group ) were significantly higher than those of eGFR ≥ 90 group (normal renal function group ) (P<0.05).Serum ICAM-1 and IL -6 concentration and eGFR value of patients with eGFR < 90 were significantly negative correlation (r=-0.9283, P=-0.013; r=-0.9369,P=0.001).Conclusion:The serum ICAM-1 and interleukin -6 levels may correlate with the renal function injury development, and its concentration detection may have potential value for evaluating the degree of renal function injury.关键词
肾功能损害/ICAM-1/IL-6/肾小球滤过率Key words
Impairment of renal function/ICAM-1/Interleukin-6/Glomerular filtration rate引用本文复制引用
石海燕,胡维维,杨秀媚,赖均鹏,刘笑芬..血清ICAM-1和IL-6水平与肾功能损害的相关性研究[J].中国医学创新,2013,(16):1-2,3,3.
