中国医学创新Issue(16)：156-159,160,5.DOI:10.3969/j.issn.1674-4985.2013.16.076
溶酶体铁代谢异常与肾脏损伤
The Abnormality of Lysosomal Iron Metabolism and Kidney Injury
许碧华 1许琛 1王丽姝 1刘华锋 1刘伟敬 1梁东1
作者信息
- 1. 广东医学院附属医院 广东 湛江 524000
- 折叠
摘要
Abstract
The lysosomal compartment is essential for a variety of cellular functions. Degradation of iron-containing macromolecules results in a large amount of low mass iron which exists in redox-active Fe(II) form in lysosomes. Fe(II) is known to catalyze Fenton reactions that may jeopardize lysosomal membrane integrity during oxidative stress. This results in the release of hydrolases and redox-active iron into the cytosol with ensuing damage or cell death. Besides,autophagy act as a crucial role in iron metabolism. Adversely affecting lysosomal iron handling can contribute to a variety of kidney diseases.关键词
溶酶体/自噬/铁代谢/肾损伤Key words
Lysosome/Autophagy/Iron metabolism/Kidney injury引用本文复制引用
许碧华,许琛,王丽姝,刘华锋,刘伟敬,梁东..溶酶体铁代谢异常与肾脏损伤[J].中国医学创新,2013,(16):156-159,160,5.
