中国医学创新Issue(17)：5-7,3.DOI:10.3969/j.issn.1674-4985.2013.17.003
金黄色葡萄球菌感染的糖尿病足患者耐药特点及临床特征
Clinical Features and Drug Resistance of Staphyloccocus Aureus Isolates from Patients with Diabetic Foot Infections
黄秉文 1卢颖瑜 1方咏红 1谭淑英1
作者信息
- 1. 广东省佛山市第二人民医院 广东 佛山 528000
- 折叠
摘要
Abstract
Objective:To investigate clinical features and antibiotic resistance of staphyloccocus aureus(SA)strains isolated from patients with diabetic foot infections(DFI)in The second people’s hospital of Foshan.Method:33 SA strains were isolated from 132 patients with diabetic foot in the hospital from Jan 2010 to Dec 2012.The clinical features of patients were summarized. Relationships between the isolates and depth of ulcer or severity of infection were analyzed. The disk-diffusion method was performed to examine antimicrobial susceptibility. Result:Gram positive(G+)and Gram negative (G-)isolates were 56.1%and 43.9%,respectively. Multidrug-resistant SA composed 48.5%of the total SA isolates. The size of ulcers with SA infections was bigger than those with non-SA bacterial infections(P<0.05).Compared to G-strains,patients with SA strains were older;and more frequently,they had osteomyelitis.Compared to G-strains,the SA strains were more frequently isolated from deeper ulcers and with long-time infections(P<0.01).The resistant rates of SA to first generation cephalosporins,second generation cephalosporins,third generation cephalosporins,fluoroquinolones,and Large ring lactones were between 38.5%-58.8%,37.6%-63.2%,33.4%-62.7%,53.5%-68.9%,and 30.2%-44.3%,respectively.Only two out of 33 SA strains was vancomycin-resistant.Conclusion:SA strains are mainly found in patients with deeper ulcers and more serious infections.Multidrug-resistant SA is common in DFI.It is important to Isolate pathogens and determine their antibiotic resistance correctly in diabetic foot patients in order to provide appropriate drug administration and to reduce the production and dissemination of drug resistant strains.关键词
金黄色葡萄球菌/糖尿病足/感染Key words
Staphyloccocus aureus/Diabetic foot/Infection引用本文复制引用
黄秉文,卢颖瑜,方咏红,谭淑英..金黄色葡萄球菌感染的糖尿病足患者耐药特点及临床特征[J].中国医学创新,2013,(17):5-7,3.
