中国医学创新Issue(18)：20-21,2.DOI:10.3969/j.issn.1674-4985.2013.18.009
阿托伐他汀联合依折麦布治疗冠心病合并高胆固醇血症临床分析
Clinical Analysis of Atorvastatin Statin combined with Ezetimibe for Coronary Heart Disease with Hypercholesterolemia4
刘淼 1牛锁成1
作者信息
- 1. 河南省濮阳市人民医院 河南 濮阳 457000
- 折叠
摘要
Abstract
Objective:To investigate the clinical efficacy and safety of atorvastatin statin combined with ezetimibe for the treatment of coronary heart disease with hypercholesterolemia. Method:72 cases of patients with coronary heart disease were randomly divided into two groups. 36 cases in the control group were treated with atorvastatin statins,while the other 36 cases in the observation group were treated with ezetimibe on the basis of t atorvastatin statins. Every two weeks was a course of treatment,and the comprehensive evaluation of efficacy and safety were estimated and compared based on the incidence of adverse reactions,and the liver and kidney function indicators after three courses. Result:High cholesterol and inflammation:After treatment,the serum TC,LDL-C and hs-CRP levels of the observation group were significantly lower than the control group(P<0.05),while there was no significant difference in the two groups of patients with HDL-C levels(P>0.05);liver and kidney damage and adverse reactions:After treatment,the ALT UN level of the observation group were significantly lower than the control group(P<0.05),while there was no significant difference in the two groups of patients with CRE levels(P>0.05).The incidence of adverse reactions of the observation group was significantly less than the control group(P<0.05). Conclusion:It is an efficient method with little clinical side effects for atorvastatin statin combined with ezetimibe to treat coronary heart disease with hypercholesterolemia which is worth to be promoted.关键词
阿托伐他汀/依折麦布/冠心病/高胆固醇血症/临床疗效/安全性Key words
Atorvastatin combined with ezetimibe/Coronary heart disease/Hypercholesterolemia/Clinical efficacy/Security引用本文复制引用
刘淼,牛锁成..阿托伐他汀联合依折麦布治疗冠心病合并高胆固醇血症临床分析[J].中国医学创新,2013,(18):20-21,2.
