中国医学创新Issue(22)：4-6,3.DOI:10.3969/j.issn.1674-4985.2013.22.002
肺结核患者合并乙肝病毒感染与发生药物性肝炎关系的队列研究
Cohort Study on the Drug-induced Hepatitis of the Pulmonary Tuberculosis Patients Co-infected with Hepatitis B Virus
许光辉 1陈志宇 1甄志斌 1蒙是升 1汤志强 1黄广军1
作者信息
- 1. 广东省江门市结核病防治所 广东 江门 529000
- 折叠
摘要
Abstract
Objective:To study the exposure-effect relationship between the pulmonary tuberculosis patients(PTB)co-infected with hepatitis B virus(HBV)and drug-induced hepatitis(DIH). Method:A prospective cohort study was conducted. A total of 87 co-infected cases newly diagnosed during the period from Oct 2009 to Feb 2012 were arranged to the exposure group(TB-HBV),while the same quantity cases were selected into the control group(TB)according to randomizing and 1:1 pair matching. Both groups patients were treated by first-line antituberculosis drugs and followed up the liver function. The datum were analyzed by SPSS 11.0.Result:The incidence rate of DIH in the exposure group was 30.8%,which was significantly higher than that in the controls 10.7%(x 2=10.336,P<0.05).Relative risk value was 2.9(x2=10.28),95%CI:1.51,5.55. Although higher transaminase level,more severe DIH and cases who needed to alternate or discontinue the regimens were observed among the TB-HBV,there were no significant difference between the two groups(P>0.05).Conclusion:HBV co-infection is one of the cause of DIH in the PTB.The co-infected patients can be treated by the standard short-course regimens with watching out of the liver function.关键词
肺结核/乙肝病毒/药物性肝炎/队列研究/发病率/相对危险度/病因Key words
Pulmonary tuberculosis/Hepatitis B virus/Drug-induced hepatitis/Cohort study/Incidence rate/Relative risk/Cause引用本文复制引用
许光辉,陈志宇,甄志斌,蒙是升,汤志强,黄广军..肺结核患者合并乙肝病毒感染与发生药物性肝炎关系的队列研究[J].中国医学创新,2013,(22):4-6,3.
