中国医学创新Issue(23)：153-156,4.DOI:10.3969/j.issn.1674-4985.2013.23.073
白细胞介素8、血管内皮生长因子在椎间盘退变中作用的研究进展
Research Progress of Interleukin-8 and Vascular Endothelial Growth Factor Effects on Interver Tebral Disk Degeneration
龙涛 1李开南2
作者信息
- 1. 遵义医学院 贵州 遵义 563003
- 2. 成都大学附属医院
- 折叠
摘要
Abstract
Objective:To summarize the recent development of interleukin-8 and vascular endothelial growth factor(VEGF)effects on intervertebral disk degeneration. Method:The related literatures were reviewed and the main achievements studies in the fields were summarized. Result:IL-8 induced vascular endothelial cell growth in tumor tissue,but the exactly mode and mechanism of IL-8 in IVDD was not unknown. As a stimulator of angiogenesis,VEGF induced vascular endothelial cell growth,whether IL-8 and VEGF express the function in Inter vertebral disk degeneration and its mechanism is not known fully well. Conclusion:IL-8 and VEGF have effect on promoting angiogenesis,and the concrete function need to further clarify. Whether can use this to promote the generation of new blood vessels in the intervertebral disk,increase blood circulation,improve the nucleus pulposus cell nutrition,so to treat,slow down or reverse the process of IVDD. Whether as one of the indicators to evaluate the patients prognosis needs further reserch. And the specific mechanism of IL-8 and VEGF is not clear,whether there is interaction needs further research.关键词
白细胞介素8/血管内皮生长因子/椎间盘退变Key words
Interleukin-8/Vascular endothelial growth factor/Intervertebral disk degeneration引用本文复制引用
龙涛,李开南..白细胞介素8、血管内皮生长因子在椎间盘退变中作用的研究进展[J].中国医学创新,2013,(23):153-156,4.
