摘要
Abstract
Objective:To observe the effect and safety of neo-adjuvant chemotherapy applied in colorectal cancer with hepatic metastasis treatment.Method:40 patients with colorectal cancer and hepatic metastasis were selected in department of oncology of Yongding hospital of Suzhou from July 2013 to July 2015. 3 cases were given FOLFIRI plan,27 cases were given FOLFOX6 plan and 10 cases were given both plans.Surgical treatment was given chemotherapy stopped after 15 days when operation conditions were obtained. Primary tumor was removed with open operation or laparoscopic surgery and metastatic liver cancer was removed by open operation.Result:The efficient of neo-adjuvant chemotherapy on metastatic lesions was 67.5%(27/40) and primary tumor was 55.0%(22/40). The positive rate of CEA in serum was 85.0%(34/40),while after neo-adjuvant chemotherapy it was 47.5%(19/40),there was statistical difference of positive rate of CEA in serum before and after neo-adjuvant chemotherapy( 字2=5.774,P<0.05),and the difference was statistically significant in serum CEA value between before and after neo-adjuvant chemotherapy (t=15.745,P<0.05). The average size of primary tumor before neo-adjuvant chemotherapy was(2.16±0.51)cm,after neo-adjuvant chemotherapy it was (1.30±0.44)cm,there was statistical difference of primary tumor size(t=4.084,P<0.05).The average size of metastatic lesions before neo-adjuvant chemotherapy was(7.64±2.18)cm, after neo-adjuvant chemotherapy it was(3.97±1.15)cm,there was statistical differences of metastatic lesions size(t=9.004,P<0.05). There were 14 patients (35.0%) given radical resection,1 case of incision infection and 1 case of liver failure,the incidence of complication was 5.0%,there was no perioperative death.Conclusion:With liver surgery improved and study of neo-adjuvant chemotherapy deeper, it is more important of neo-adjuvant chemotherapy for prognosis of colorectal cancer with hepatic metastasis patients.关键词
新辅助化疗/结直肠癌/肝转移癌/预后/生存率Key words
Neo-adjuvant chemotherapy/Colorectal cancer/Metastatic liver cancer/Prognosis/Survival rate
