中国医学创新Issue(31)：4-6,3.DOI:10.3969/j.issn.1674-4985.2015.31.002
乌司他丁对多发伤患者凝血功能和预后影响的研究
The Impact of Ulinastatin on Coagulation Function and Prognosis in Multiple Trauma Patients
摘要
Abstract
Objective:To investigate the effect of early application of ulinastatin on coagulation system and clinical outcomes in multiple trauma patients.Method:40 multiple trauma patients were selected in our ICU from July 2013 to July 2014 and randomly divided into common treatment group and ulinastatin group,20 cases in each group. The injury severity score (ISS) were more than 16 points in all patients. Common group was given conventional treatment, while ulinastatin group was treated intravenous infusion of ulinastatin immediately after admission on the basis of routine therapy. The dose of ulinastatin was 40 kU every 12 hours. Dynamic observation of the changes of the platelet count (PLT), thrombin time (TT), prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (FIB) and D-dimer (D-D) of two groups before and after treatment(3,5 and 7 days) were compared.At the same time, the acute physiology and chronic health score(APACHE II),ICU hospitalization days, MODS incidence and 28 day mortality were recorded.Result:There were no statistical differences between ISS score, APACHE II score and coagulation function on admission of two groups (P>0.05). After treatment, the improvement of the PLT,TT,PT,APTT,FIB and D-D were better in ulinastatin group than that common group, the differences were statistically significant(P<0.05).The MODS incidence, 28 day mortality and ICU hospitalization days of ulinastatin group were significantly lower than common group,the differences were statistically significant(P<0.05).Conclusion:Ulinastatin injection could improve PLT,TT,PT,APTT,FIB and D-D;decrease MODS incidence, 28 d mortality and ICU hospitalization days in traumatic coagulopathy patients.关键词
多发伤/凝血功能/乌司他丁Key words
Multiple trauma/Coagulation function/Ulinastatin引用本文复制引用
蔡金芳,黄秀英,朱念,盛鹰,高波,金文静,王志华,谢晓洪,王静恩..乌司他丁对多发伤患者凝血功能和预后影响的研究[J].中国医学创新,2015,(31):4-6,3.基金项目
上海市卫生计生委科技项目 （）
