中国医学创新Issue(31)：39-41,42,4.DOI:10.3969/j.issn.1674-4985.2015.31.013
呼吸末正压通气对老年腹腔镜手术麻醉患者脑氧代谢和认知功能的影响
The Cerebral Oxygen Metabolism and Cognitive Function Effect of Positive end Expiratory Pressure Anesthesia in Elderly Laparoscopic Operation
摘要
Abstract
Objective:To investigate the cerebral oxygen metabolism and cognitive function effect of positive end expiratory pressure anesthesia in elderly laparoscopic operation.Method:100 laparoscopic operation in elderly ASA I-II patients in our hospital were selected from 2014 January to 2015 April and randomly divided into two groups, study group of 52 cases,they were given PEEP 5 cm H2O;control group of 48 cases,they were given PEEP 0 cmH2O. The SjvO2,CaO2-CjvO2 and CERO2 in pre-pneumoperitoneum (T0),1 h post-pneumoperitoneum (T1) and 2 h post-pneumoperitoneum (T2) of two groups were compared,the cognitive function (MMSE score) pre-operation and post-operation of two groups were compared.Result:At T0, two groups had no statistically significant difference in SjvO2, CaO2-CjvO2 value and CERO2(P>0.05);the above indexes at T1,T2 of study group were significantly lower than that control group the differences were statistically significant(P<0.05).At pre-operative ,the MMSE score of two groups had no statistically significant difference(P>0.05);after 1-7 d operation,MMSE score of study group was significantly higher than that control group, the cognitive dysfunction incidence rate was significantly lower than that control group, the difference was statistically significant(P<0.05).Conclusion:Positive end expiratory pressure helps to significantly improve cerebral oxygen metabolism balance during anesthesia in elderly laparoscopic operation, it can reduce the risk of postoperative cognitive dysfunction.关键词
呼吸末正压通气/老年/腹腔镜手术/麻醉Key words
Positive end expiratory pressure/Elderly/Laparoscopic operation/Anesthesia引用本文复制引用
陈业松,吴熠,李书庸,刘明..呼吸末正压通气对老年腹腔镜手术麻醉患者脑氧代谢和认知功能的影响[J].中国医学创新,2015,(31):39-41,42,4.基金项目
中山市医学科研基金 （）
