中国癌症防治杂志Issue(2)：130-133,134,5.DOI:10.3969/j.issn.1674-5671.2013.02.11
IGFBP4和PAPPA在非小细胞肺癌中的表达及临床意义
Expression and clinical significance of IGFBP4 and PAPPA in non-small cell lung cancer
摘要
Abstract
Objective To investigate the expression and clinical significance of IGFBP4 and PAPPA in patients with non-small cell lung cancer(NSCLC). Methods Total RNA was extracted from 55 pairs of NSCLC tissues and adjacent noncancerous tissues.IGFBP4 and PAPPA expression was detected using real-time quantitative RT-PCR. Results IGFBP4 expression was significantly lower in NSCLC tissue than in adjacent lung tissue,but significantly higher than in normal lung tissue(P<0.05).IGFBP4 expression was signif-icantly higher in squamous carcinoma tissues than in adenocarcinoma.Furthermore,survival was longer in patients with high IGFBP4 expression than in those with low expression(P<0.05).However,IGFBP4 expression did not correlate with age,gender,histological dif-ferentiation grade or lymph node metastasis.PAPPA expression was significantly higher in NSCLC tissue than in adjacent or normal lung tissue(P<0.05).PAPPA expression was higher in cases of adenocarcinoma or lymph node metastasis than in cases of squamous carcinoma or cases without lymph node metastasis(P<0.05).Survival was shorter in patients expressing high levels of PAPPA than in those expressing low levels(P<0.05).However,PAPPA expression was not related with age,sex or clinical stage.There was a signifi-cant positive correlation between IGFBP4 and PAPPA expression in NSCLC tissues (r=0.512,P=0.000). Conclusions IGFBP4 and PAPPA may correlate with tumor growth in NSCLC,and may be useful as molecular prognostic indicators of NSCLC.关键词
肺肿瘤/非小细胞肺癌/IGFBP4/PAPPA/实时荧光定量PCRKey words
Lung neoplasms/Non-small cell lung cancer/IGFBP4/PAPPA/Real-time quantitative RT-PCR分类
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..IGFBP4和PAPPA在非小细胞肺癌中的表达及临床意义[J].中国癌症防治杂志,2013,(2):130-133,134,5.基金项目
广西自然科学基金资助项目 （）
