中国药业Issue(20)：21-23,3.
吗氯贝胺与阿米替林对照治疗抑郁症的系统评价
Systematic Review on Moclobemide vs Amitriptyline for Treating Depression
摘要
Abstract
Objective To compare the clinical efficacy and adverse reactions of moclobemide vs amitriptyline in treating depres-sion.Methods Totally 8 randomized controlled trails (RCTs)literatures of moclobemide vs amitriptyline in treating depression were re-trieved from 1994 to 2014 and evaluated by systematic evaluation method.Results The clinical efficacy between moclobemide and amitriptyline had no significant difference [P >0.05,OR=1.28,95%CI(0.79~2.08)].the incidences of ADR was 9.76% in mo-clobemide group,which was significantly lower than 23.62% in amitriptyline group(P <0.05).The incidences of adverse reactions such as tremor,dry mouth,palpitation,drowsiness,blurred vision,constipation,tachycardia,dysuria in moclobemide group were significantly lower than that of amitriptyline group(χ2=4.99,P <0.05),but insomnia,agitation in moclobemide group were significantly higher than that of the amitriptyline group(χ2 =6.68,P <0.01 ).There was no significant difference of others adverse events between the two groups (P >0.05 ).Conclusion Moclobemide and amitriptyline have the same effect for treating depression,but the incidence of mo-clobemide is lower.关键词
吗氯贝胺/阿米替林/抑郁症/系统评价Key words
moclobemide/amitriptyline/depression/systematic review分类
医药卫生引用本文复制引用
杜彪,杜扬,张杰,谢星星,刘俊香..吗氯贝胺与阿米替林对照治疗抑郁症的系统评价[J].中国药业,2015,(20):21-23,3.基金项目
重庆市科技攻关项目，项目编号CSTC，2009AC5195；重庆市万州区科技计划项目，项目编号201403055。 （）
