中国药业2015，Vol.24Issue(21)：41-43,3.
新生儿败血症与绒毛膜羊膜炎的相关性及美罗培南的疗效
Correlation between Neonatal Septicemia and Chorioamnionitis and the Efficacy of Meropenem
摘要
Abstract
Objective To study the correlation between neonatal septicemia and chorioamnionitis and the Safety of meropenem. Methods 150 cases of neonatal septicemia admitted to the hospital from April to December 2014 was divided into the study group ( 75 cas-es ) and control group ( 75 cases ) . The control group was treated with conventional anti-infection treatment, and the study group re-ceived meropenem. Results 120 cases out of 150 cases of neonatal sepsis were with chorioamnionitis, the rate was 80. 00%, forming an important pathogenic factor in neonatal septicemia. APACHEⅡscores and SOFA scores of the two groups before and after treatment had statistically significant difference ( P < 0. 05 ) , indicators in both groups improved; the two indicators after treatment between the two group had statistically significant difference, and the study group improved more ( P < 0. 05 ) . Before treatment, the patient's CRP, PCT, CD64 value difference was not statistically significant ( P > 0. 05 ) , after treatment, compared two groups of patients before treatment were significantly lower ( P < 0. 05 ) , the study group improved more significantly than the control group ( P < 0. 05 ) . Study group received 2 courses of treatment, and the clinical total effective rate was 86. 67%, which was higher than 60. 00% of the control group, and the difference was statistically significant ( P < 0. 05 ) . Conclusion Chorioamnionitis is an important factor in the pathogenesis of neonatal sepsis; in the treatment of neonatal sepsis meropenem has significant clinical efficacy, can reduce the body's inflammatory response to prevent disease progression, and promote the body's recovery.关键词
新生儿败血症/绒毛膜羊膜炎/美罗培南/疗效Key words
neonatal sepsis/chorioamnionitis/meropenem/efficacy分类
医药卫生引用本文复制引用
杨宇艳,高世泉,高彩云,闫爱霞,才海燕,郭丽侠..新生儿败血症与绒毛膜羊膜炎的相关性及美罗培南的疗效[J].中国药业,2015,24(21):41-43,3.基金项目
2014年河北省秦皇岛市科技计划(第一批)项目,项目编号:201401A240. （第一批）
