摘要
Abstract
Objective To investigate the clinical efficacy and its influence of early vitamin D supplementation on the immune function of preterm infants. Methods 300 cases of premature infants in the hospital were selected and randomly divided into two groups, 150 cases in each group. The control group was given formula fed neonatal while the study group began to received supplement vitamin D (500 U/d ) at 3 d on the basis of the control group, with a continuous treatment of 7 d. Results The calcium, phosphorus, clear Ca × P and 25-( OH ) D levels of premature infants in the study group after the experimental were ( 2. 24 ± 0. 15 ) mmol/L, ( 1. 23 ± 0. 08 ) mmol/L, ( 34. 34 ± 3. 54 ) and ( 31. 75 ± 3. 84 ) mmol/L, which were increased significantly than before the experiment and the control group ( P <0. 05 );the immunoglobulin of IgA, IgM and IgG levels in the premature infants of the study group after the experiment were increased slightly but the difference was not statistically significant ( P > 0. 05 ) when compared with before treatment;the immunoglobulin of IgA, IgM and IgG levels of the control group after the experiment were slightly reduced when compared with before treatment, but the differ-ence was not statistically significant ( P > 0. 05 );there was no significant difference between the two groups on each index ( P > 0. 05 );IL-2 level of the control group had no significant changes after the experiment ( P > 0. 05 ) , while the IL-2 levels in the study group after the experiment were significantly increased than before the experiment and control group ( P < 0. 05 ) . Conclusion Early postnatal supplementation of vitamin D is one of the important measures of health support for the premature infants, which can improve the im-munity of premature infants that has a certain value in clinical application.关键词
早产儿/维生素D/免疫功能Key words
premature/vitamin D/immune function分类
医药卫生
