中国药业2015，Vol.24Issue(21)：186-188,3.
重组牛碱性成纤维细胞生长因子联合重组人表皮生长因子治疗角膜深层铁屑异物60例
Clinical ObserVation of Epidemic Growth Factor Combined with Basic Fibroblast Growth Factor in treating Deep Corneal Foreign Bodies
摘要
Abstract
Objective To observe the clinical effect of epidemic growth factor combined with basic fibroblast growth factor in treating deep corneal iron foreign bodies. Methods 180 eyes of 180 patients with deep corneal iron foreign body were randomly divided into experimental group and control group 1 & 2, 60 eyes in each group. 180 cases underwent annular separation whole removal, then experi-mental group were given levofloxacin eye drops and epidemic growth factor eye drops and basic fibroblast growth factor gel for eye. Control group 1 was given levofloxacin eye drops and epidemic growth factor eye drops without basic fibroblast growth factor gel for eye. Control group 2 was given levofloxacin eye drops and basic fibroblast growth factor gel for eye without epidemic growth factor eye drops. Patients visited on the 3rd, 5th, 7th, 9th, 12th day after removal of corneal foreign bodies and the ocular symptoms, wound healing of the cornea, corneal fluorescein staining were observed. Results On the 5th day after removal of deep corneal foreign body, the total effective rate in experiment group was 83. 33%, and 66. 67% in control group 1 (χ2=32. 98, P=0. 011 ) , and 68. 33% in control group 2, compare with the experimental group (χ2=31. 09, P=0. 013 ) . On the 9th day after removal of corneal foreign body, the total effective rate in experiment group was 96. 67%, and 85. 00% in control group 1 (χ2=33. 26, P=0. 014 ) , and 81. 67% in control group 2, com-pare with the experimental group (χ2=35. 47, P=0. 011 ) . Corneal healing time on average of experimental group was ( 5. 35 ± 0. 23 ) d, and ( 7. 12 ± 0. 25 ) d in control group 1 ( t=2. 532, P=0. 018 ) , and ( 7. 36 ± 0. 31 ) d in control group 2, compare with the experimental group ( t=2. 653, P=0. 016 ) . Conclusion The combination of epidemic growth factor eye drops and basic fibroblast growth factor gel for eye is more effect than they are used alone in treatment of deep corneal iron foreign bodies. They can significantly speed up the repair of corneal wound healing, the effect is remarkable.关键词
重组人表皮生长因子/重组牛碱性成纤维细胞生长因子/环形分离整体剔除/角膜深层铁屑异物Key words
epidemic growth factor eye drops/basic fibroblast growth factor gel for eye/annular separation whole corneal foreign body removal/deep corneal iron foreign bodies分类
医药卫生引用本文复制引用
张志萍..重组牛碱性成纤维细胞生长因子联合重组人表皮生长因子治疗角膜深层铁屑异物60例[J].中国药业,2015,24(21):186-188,3.基金项目
2015年河北省秦皇岛市科学技术研究与发展计划(第二批)项目,项目编号:201502A100. （第二批）
