摘要
Abstract
Objective To discuss the effect of mifepristone cooperating with misoprostol on the induction of labor in pregnancy from 12 to 20 weeks. Methods 47 pregnant women of 12-20 weeks were randomly divided into two groups.The observation group were given drug induction and the discharge of residual pregnancy tissue within 24 hours were observed.The successful cases were followed up.The patients with incomplete abortion were done curettage immediately,and artificial rupture of membrane were done for few non-successful cases on the basis of drug induction. The control group were given curettage and amniocentesis induction by rivanol. Results In the observation group,the patients with complete abortion accounted for 90.625%,the patients with incomplete abortion accounted for 3.125%,the non-successful cases accounted for 6.250%.Curettage combined with drug induction could ease patients’suffering and reduce the incidence of complications for the patients with incomplete abortion by intenerate and expand cervix,which could simplify and shorten the procedure.6.25% non-successful patients were transformed into complete abortion through artificial rupture of membrane.In the control group,all of the cases underwent intrauterine manipulation consisting of 10 cases with curettage and 5 cases with amniocentesis induction by rivanol,which lead to more bleeding and pain. Conclusion Mifepristone cooperating with misoprostol on the induction of labor in pregnancy of 12-20 weeks has a better effect,less pain,less damage and better recovery.The patients' pain can be relieved obviously due to the dilatation of cervix and easy manipulation in the curettage for the patients with incomplete abortion. Artificial rupture of membrane for non-successful cases can improve the successful rate of drug induction,which is safe,effective,and worth recommending.关键词
米非司酮/米索前列醇/人工破膜/药物流产Key words
Mifepristone/Misoprostol/Artificial rupture of membranes/Medical abortion分类
医药卫生
