中国医药科学Issue(13)：49-52,4.
阿奇霉素滴眼液的生产工艺筛选及稳定性研究
Studyonproductionprocessesandstabilityofazithromycineyedrops
王淑娟 1赵晓红 1张晓明 2王勇军 1杨绪跃2
作者信息
- 1. 常州市亚邦医药研究所有限公司，江苏常州213163
- 2. 江苏亚邦爱普森药业有限公司，江苏盐城224599
- 折叠
摘要
Abstract
Objective To investigate the effect of production processes on stability of azithromycin eye drops,we screen the optimal procedure by the influencing factor experiments including illumination and high temperature,then provide a reference to the practical production. Methods According to the drops workshop conditions,evaluate the four procedures and determine the optimization by the characteristics, assay and impurity in the influencing factor experiments. Results Azithromycin eye drops is sensitive to heat and light,and trend to be degraded with high temperature sterilization step. Conclusion The result show that the third procedure is optimal, the azithromycin eye drops should be stored at low temperatures from light;In additon,the procedure should be avoid to high temperature.关键词
阿奇霉素/滴眼液/工艺/稳定性Key words
Azithromycin/Drops/Procedure/Stability分类
医药卫生引用本文复制引用
王淑娟,赵晓红,张晓明,王勇军,杨绪跃..阿奇霉素滴眼液的生产工艺筛选及稳定性研究[J].中国医药科学,2013,(13):49-52,4.
